Scientific and general program of the First Symposium of the IIfTC

"The Ischemic myocardium. Definitions, Measurements and Pathophysiology"

Scientific program

Welcome and Introduction
Jochen Schaefer and Thomas Kenner
IIfTC, Bad Orb
and
Physiologisches Institut der Universität Graz, Graz
Is there a role for epistemology and philosophy of medicine in cardiovascular research?

Session I: Myocardial Ischemia - definitions, models and methods
Chairman: Kiichi Sagawa

Kiichi Sagawa
Department of Biomedical Engineering
The Johns Hopkins University, Baltimore, Maryland
Defining coronary ischemia: skinning an onion?

Derek Yellon
The Rayne Institute, St. Thomas' Hospital London, London
Evolving Myocardial Infarction: Animal Models, Experimental Methods and Pharmacological Manipulations

Tetsuji Miura
Department of Physiology
University of South Alabama, Mobile, Alabama
The determinants of Myocardial Infarct Size

James M. Downey
Department of Physiology
University of South Alabama, Mobile, Alabama
Free Radicals and Ischemia

John Kingma
The Rayne Institute, St. Thomas' Hospital London, London
Infarct Size Limitation: Is there A Role for Combination Therapy?

Keith A. Reimer
Department of Physiology
Duke University Medical Center, Durham, North Carolina
Myocardial Ischemia, Reperfusion, and 'Reperfusion Injury'

Charles E. Murry
Department of Pathology
Duke University Medical Center, Durham, North Carolina
Altering the Myocardial Response to Ischemic Injury by Ischemic Preconditioning

Session II: "Meta-cardiology" -- analysis of approaches to studying the ischemic myocardium
Chairman: Jochen Schaefer

Kenneth Schaffner
Department of History and Philosophy Seminar
University of Pittsburgh, Pittsburgh, Pennsylvania
Relations between "Risk Factors" and "Pathogenetic Mechanisms" of the Ischemic Myocardium: Two Types of Causation

Reidar K. Lie
Department of Philosophy
University of Minnesota, Minneapolis, Minnesota
and
Institutt for anatomi
Universitetet i Bergen, Bergen
Experimental evidence and theory confirmation - an analysis of the 'border-zone' controversy

Hermann Eichstädt
Universitätsklinikum Charlottenburg
Freie Universität Berlin, Berlin
Role of "high technology equipment" in cardiological diagnosis: dictated by industrial interests or clinical needs?

Thomas Kenner
Physiologisches Institut der Universität Graz
Graz
Importance and application of modelling in cardiovascular research

Session III: Pathophysiology
Chairman: Thomas Kenner

Thies Peters
Institut für Experimentelle Medizin
Janssen GmbH, Neuss
Potassium in hypoxia and ischemia

Kiichi Sagawa
Department of Biomedical Engineering
The Johns Hopkins University, Baltimore, Maryland
The energetics of ventricular contraction (Suga's PVA concept)

Dan Burkhoff and David Yue
Department of Biomedical Engineering
The Johns Hopkins University, Baltimore, Maryland
The concept of downregulation and its experimental foundations

Max J. Lab and S. Dilly
Department of Physiology
Charing Cross and Westminster Medical School, London
Mechano-elastic oscillation in ischaemic myocardium

S. Dilly and Max J. Lab
Department of Physiology
Charing Cross and Westminster Medical School, London
Electrophysiological alternans modelled as a harmonic in ischaemic myocardium

Michael R. Franz
Cardiac Arrhythmia Study Unit
Stanford University Medical Center, Stanford, California
Monophasic action potential measurements as an indicator of myocardial ischemia

Final Discussions and Conclusions
Chairmen: Thomas Kenner and Jochen Schaefer