| November 18, 1988 | 
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          | 7.00 | 
          Reception, Greenville Room, Hilton Inn | 
        
         
          | 8.00 | 
          Dinner, Hilton Inn | 
        
         
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          | November 19, 1988 | 
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          | Morning session: | 
          Methodological and Philosophical 
            Issues (Chair: Reidar Lie) | 
        
         
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          | 9.00 | 
          Welcome and Introduction 
            Reidar K. Lie, East Carolina University 
            Jochen Schaefer, IIfTC, FRG | 
        
         
          | 9.15 | 
          William Dupont, Ph.D.: Sequential 
            stopping rules and sequentially adjusted F-values. Does one require 
            the other? | 
        
         
          | 9.45 | 
          Fred Gifford, Ph.D.: Stopping rules: An 
            assessment of proposals by Meier and Kadane | 
        
         
          | 10.15 | 
          Coffee | 
        
         
          | 10.45 | 
          Teddy Seidenfeld, Ph.D.: On the ethics 
            of a new clinical trial | 
        
         
          | 11.15 | 
          Kenneth Schaffner, M.D., Ph.D.: Statistical 
            and individual concepts of causation | 
        
         
          | 12.00 | 
          Luncheon (Brody Building, ECU School of Medicine, 2W-38) | 
        
         
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          | Afternoon session: | 
          Clinical experience (Chair: 
            Jochen Schaefer) | 
        
         
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          | 13.30 | 
          Arthur Moss, M.D.: Interpretation 
            and significance of two or three way interactions in clinical trials | 
        
         
          | 14.00 | 
          Bert Spilker, M.D., Ph.D.: Who interprets 
            clinical data: clinician or statistician? | 
        
         
          | 14.30 | 
          Larry Friedman, M.D.: Selected design 
            issues in cardiovascular clinical trials | 
        
         
          | 15.00 | 
          Coffee | 
        
         
          | 15.30 | 
          Franz Ebner, M.D.: Problems in the 
            translation of clinical trials to clinical practice | 
        
         
          | 16.00 | 
          Rein Vos, M.D.: The paradox of generating 
            and validating clinical hypotheses | 
        
         
          | 16.30 | 
          Discussion and concluding remarks | 
        
         
          | 17.15 | 
          Transportation back to hotel | 
        
         
          | 19.00 | 
          Dinner, King and Queen, 103 Eastbrook Drive | 
        
         
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          | November 20, 1988 | 
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          Discussion (Chair: Kenneth 
            Schaffner) | 
        
         
          |   | 
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          | 9.00-11.30 | 
          Informal discussions among the participants of the symposium | 
        
         
          | 11.30 | 
          Lunch | 
        
         
          | 13.00 | 
          Departure from Greenville |